DoD Peer Reviewed Orthopaedic, Clinical Translational Research Award | HT942524PRORPCTRA

Opportunity Information: Apply for HT942524PRORPCTRA

The Department of Defense (DoD) Peer Reviewed Orthopaedic Clinical Translational Research Award (PRORP CTRA) aims to support high-impact clinical research focused on improving the diagnosis, treatment, rehabilitation, and prevention of orthopaedic injuries affecting military personnel and civilians. These injuries, which account for a significant portion of military trauma cases, can impact military readiness, return to duty, and long-term health outcomes.

This funding opportunity supports clinical research that translates emerging techniques and interventions into clinical settings, influencing standards of care and evidence-based treatment guidelines. Key areas of focus include optimizing treatment approaches, minimizing complications, and improving functional recovery. While military-focused, the research must also be relevant to the general population with major orthopaedic injuries.

The PRORP CTRA allows for clinical research that may or may not include clinical trials, distinguishing it from the Clinical Trial Award (CTA), which exclusively funds clinical trials. Supported research may involve studies on human subjects, biomarker development, imaging diagnostics, health disparities, and outcomes research but must exclude animal studies and entirely retrospective or database-only research.

Applicants must provide: - **Preliminary Data** relevant to the proposed study. - **Study Population Strategy** demonstrating access to an appropriate patient group and a plan for inclusive recruitment. - **Availability of Intervention** ensuring access to required drugs, devices, or treatments. - **Statistical Plan** with a clear methodology, sample size justification, data management strategy, and compliance with regulatory standards. - **Regulatory Compliance** if investigational drugs or devices are involved, requiring alignment with FDA or equivalent agency regulations.

Proposals related to women's health are encouraged, particularly in understanding sex-specific differences in orthopaedic conditions. Studies solely focused on women's health may also consider a separate funding mechanism under PRORP.

The total anticipated budget for the award is **$6 million**, funding approximately four projects, with a maximum of **$1.5 million** per award. Projects funded under this opportunity will be awarded by **September 30, 2025**, with funds available for use until **September 30, 2030**. Selection is contingent on funding availability, application quality, and programmatic priorities.

• The Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Peer Reviewed Orthopaedic, Clinical Translational Research Award" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
• This funding opportunity was created on 2024-05-09.
• Applicants must submit their applications by 2024-09-17. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2025.)
• The number of recipients for this funding is limited to 4 candidate(s).
• Eligible applicants include: Unrestricted.

Apply for HT942524PRORPCTRA

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal: